Lei Wang

Professor
Email：wangleiwanglei@fudan.edu.cn

Biography
Lei Wang Ph.D. is a Professor of Medical Genetics in Fudan University. Wang’s research focused on reproductive genetics. He is investigating on genetic basis and molecular mechanism of diseases responsible for female infertility, including oocyte maturation arrest, early embryonic arrest, Polycystic Ovary Syndrome, et al. He was the first to show oocyte maturation arrest (MIM:616780) is a new Mendelian disease and he identified the first and second disease-causing genes (TUBB8 and PATL2) for the disease. Besides, he also identified a few novel genes responsible for other kinds of female infertility. His work incorporate disease pedigree, population cohort, cell model and mouse model to identify pathogenic genes responsible for diseases related to female infertility and its molecular mechanism. The findings will provide molecular biomarkers for quality evaluation of oocytes and embryos, help patients having precision genetic diagnosis and pave the way for the future treatment.  

Education and Position

• 2016-          Professor, Fudan University

• 2011-2016  Associate Professor, Fudan University

• 2011-2009  Assistant Professor, Fudan University

• 2004-2009  Shanghai Jiao Tong University, Ph.D.

Awards and Honors

• 2023  Xplorer Prize

• 2022  Special Award of the China Youth Science and Technology Award
  

• 2021  Chief Scientist of the National Key R&D Program

• 2020  The first prize in Shanghai Natural Science Award

• 2020  VCANBIO Award for Biosciences and Medicine

• 2019  Tan Jiazhen Life Science Innovation Award

• 2019  National High Level Talent Program

• 2018  The “Dawn”Program of Shanghai Education Commission

• 2017  National Science Fund for Distinguished Young Scholars

• 2017  Youth Science and technology innovation leader of Science and Technology of China

• 2017  The first prize in National Women’s health Award

• 2016  Shanghai Science and Technology Rising Star

• 2015  The second prize in National Women’s health Award

Selected publication

1. Wu T, Luo Y, Zhang M, Chen B, Du X, Gu H, Xie S, Pan Z, Yu R, Hai R, Niu X, Hao G, Jin L, Shi J, Sun X, Kuang Y, Li W*, Sang Q*, Wang L*. Mechanisms of minor pole-mediated spindle bipolarization in human oocytes. Science. 2024 Aug 23;385(6711):eado1022.

2. Wu T, Dong J, Fu J, Kuang Y, Chen B, Gu H, Luo Y, Gu R, Zhang M, Li W, Dong X, Sun X*, Sang Q*, Wang L*.The mechanism of acentrosomal spindle assembly in human oocytes. Science. 2022 Nov 18; 378(6621): eabq7361. 

3. Sang Q, Ray PF, Wang L*.Understanding the genetics of human infertility. Science. 2023 Apr 14;380(6641):158-163.

4. Wang W, Miyamoto Y, Chen B, Shi J, Diao F, Zheng W, Li Q, Yu L, Li L, Xu Y, Wu L, Mao X, Fu J, Li B, Yan Z, Shi R, Xue X, Mu J, Zhang Z, Wu T, Zhao L, Wang W, Zhou Z, Dong J, Li Q, Jin L, He L, Sun X, Lin G, Kuang Y*, Wang L* and Sang Q*.Karyopherin α deficiency contributes to human preimplantation embryo arrest. J Clin Invest. 2023 Jan 17;133(2):e159951.

5. Zhang Z, Li B, Fu J, Li R, Diao F, Li C, Chen B, Du J, Zhou Z, Mu J, Yan Z, Wu L, Liu S, Wang W, Zhao L, Dong J, He L, Liang X, Kuang Y, Sun X, Sang Q*, Wang L*. Bi-allelic missense pathogenic variants in TRIP13 cause female infertility characterized by oocyte maturation arrest. Am J Hum Genet. 2020 Jul 2;107(1):15-23.

6. Sang Q*, Zhang Z, Shi J, Sun X, Li B, Yan Z, Xue S, Ai A, Lyu Q, Li W, Zhang J, Wu L, Mao X, Chen B, Mu J, Li Q, Du J, Sun Q, Jin L, He L, Zhu S, Kuang Y*, Wang L*. A pannexin 1 channelopathy causes human oocyte death. Sci Transl Med. 2019 Mar 27;11(485): eaav8731.

7. Sang Q*, Li B, Kuang Y, Wang X, Zhang Z, Chen B, Wu L, Lyu Q, Fu Y, Yan Z, Mao X, Xu Y, Mu J, Li Q, Jin L, He L, Wang L*. Homozygous mutations in WEE2 cause fertilization failure and female infertility. Am J Hum Genet. 2018 Apr 5;102(4):649-657.

8. Chen B, Zhang Z, Sun X, Kuang Y, Mao X, Wang X, Yan Z, Li B, Xu Y, Yu M, Fu J, Mu J, Zhou Z, Li Q, Jin L, He L, Sang Q*, Wang L*. Biallelic mutations in PATL2 cause female infertility characterized by oocyte maturation arrest. Am J Hum Genet. 2017 Oct 5;101(4):609-615.

9. Xu Y, Shi Y, Fu J, Yu M, Feng R, Sang Q, Liang B, Chen B, Qu R, Li B, Yan Z, Mao X, Kuang Y, Jin L, He L, Sun X*, Wang L*. Mutations in PADI6 cause female infertility characterized by early embryonic arrest. Am J Hum Genet. 2016 Sep 1;99(3):744-752.

10. Feng R, Sang Q, Kuang Y, Sun X, Yan Z, Zhang S, Shi J, Tian G, Luchniak A, Fukuda Y, Li B, Yu M, Chen J, Xu Y, Guo L, Qu R, Wang X, Sun Z, Liu M, Shi H, Wang H, Feng Y, Shao R, Chai R, Li Q, Xing Q, Zhang R, Nogales E, Jin L, He L, Gupta ML Jr, Cowan NJ*, Wang L*. Mutations in TUBB8 and human oocyte meiotic arrest. N Engl J Med. 2016 Jan 21;374(3):223-232.