桑   庆

研究员，博导，课题组长，复旦大学生物医学研究院。

国家杰出青年科学基金（2023）

邮箱：sangqing@fudan.edu.cn

研究方向

聚焦女性生殖疾病的遗传学。重点围绕人类卵子受精异常及早期胚胎停滞的遗传机制展开研究。自2013年以来，以第一作者或通讯作者 (含并列) 在N Engl J Med, Science, J Clin Invest, Sci Transl Med, Genom Biol, Am J Hum Genet等期刊发表SCI论文40余篇。发现启动人类卵母细胞纺锤体组装关键结构huoMTOC；阐明人类合子分裂失败的首个致病基因BTG4及机制；揭示新发突变在人卵母细胞成熟和早期胚胎发育中的关键作用；发现核转运蛋白缺陷导致人类早期胚胎停滞的新机制。相关分子指标已被广泛应用于临床不孕患者检测中。

荣誉与奖励

• 国家杰出青年科学基金（2023）

• 上海市优秀学术带头人（2021）
  

• 上海市自然科学一等奖（2020）

• 国家优秀青年科学基金（2018）

• 全国妇幼健康科技奖自然科学一等奖（2017）

• 中国动物学会生殖生物学分会第二届青年科技奖（2017）

• 全国妇幼健康科技奖自然科学二等奖（2015）

  
  

代表成果

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1. Wang W, Miyamoto Y, Chen B, Shi J, Diao F, Zheng W, Li Q, Yu L, Li L, Xu Y, Wu L, Mao X, Fu J, Li B, Yan Z, Shi R, Xue X, Mu J, Zhang Z, Wu T, Zhao L, Wang W, Zhou Z, Dong J, Li Q, Jin L, He L, Sun X, Lin G, Kuang Y*, Wang L* and Sang Q*.Karyopherin α deficiency contributes to human preimplantation embryo arrest. J Clin Invest. 2023 Jan 17;133(2):e159951.

2. Li Q, Zhao L, Zeng Y, Kuang Y, Guan Y, Chen B, Xu S, Tang B, Wu L, Mao X, ; Sun X, Shi J, Xu P, Diao F, Xue S, Bao S, Meng  Q, Yuan P, Wang W, Ma N, Song D, Xu B, Dong J, Mu J, Zhang Z, Fan H, Gu H, Li Q, He L, Jin L, Wang L*, Sang Q*, Large-scale analysis of de novo mutations identifies risk genes for female infertility characterized by oocyte and early embryo defects.Genome Biol. 2023 Apr 06;24(68).

3. Wu T, Luo Y, Zhang M, Chen B, Du X, Gu H, Xie S, Pan Z, Yu R, Hai R, Niu X, Hao G, Jin L, Shi J, Sun X, Kuang Y, Li W*, Sang Q*, Wang L*. Mechanisms of minor pole-mediated spindle bipolarization in human oocytes. Science. 2024 Aug 23;385(6711):eado1022.

4. Wu T, Dong J, Fu J, Kuang Y, Chen B, Gu H, Luo Y, Gu R, Zhang M, Li W, Dong X, Sun X*, Sang Q*, Wang L*.The mechanism of acentrosomal spindle assembly in human oocytes. Science. 2022 Nov 18; 378(6621): eabq7361. 

5. Sang Q, Ray PF, Wang L*.Understanding the genetics of human infertility. Science. 2023 Apr 14;380(6641):158-163.

6. Wang L*, Sang Q*. MOS is a novel genetic marker for human early embryonic arrest and fragmentation. EMBO Mol Med. 2021 Dec 7;13(12):e15323.

7. Zheng W, Zhou Z, Sha Q, Niu X, Sun X, Shi J, Zhao L, Zhang S, Dai J, Cai S, Meng F, Hu L, Gong F, Li X, Fu J, Shi R, Lu G, Chen B, Fan H, Wang L, Lin G*, Sang Q*. Homozygous mutations in BTG4 cause zygotic cleavage failure and female infertility. Am J Hum Genet. 2020 Jul 2;107(1):24-33.

8. Zhao L, Xue S, Yao Z, Shi J, Chen B, Wu L, Sun L, Xu Y, Yan Z, Li B, Mao X, Fu J, Zhang Z, Mu J, Wang W, Du J, Liu S, Dong J, Wang W, Li Q, He L, Jin L, Liang X, Kuang Y, Sun X, Wang L*, Sang Q*. Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development. Protein Cell. 2020 Dec;11(12):921-927.

9. Sang Q*, Zhang Z, Shi J, Sun X, Li B, Yan Z, Xue S, Ai A, Lyu Q, Li W, Zhang J, Wu L, Mao X, Chen B, Mu J, Li Q, Du J, Sun Q, Jin L, He L, Zhu S, Kuang Y*, Wang L*. A pannexin 1 channelopathy causes human oocyte death. Sci Transl Med. 2019 Mar 27;11(485): eaav8731.

10. Sang Q*, Li B, Kuang Y, Wang X, Zhang Z, Chen B, Wu L, Lyu Q, Fu Y, Yan Z, Mao X, Xu Y, Mu J, Li Q, Jin L, He L, Wang L*. Homozygous mutations in WEE2 cause fertilization failure and female infertility. Am J Hum Genet. 2018 Apr 5;102(4):649-657.

11. Feng R^#, Sang Q^#, Kuang Y^#, Sun X^#, Yan Z^#, Zhang S^#, Shi J, Tian G, Luchniak A, Fukuda Y, Li B, Yu M, Chen J, Xu Y, Guo L, Qu R, Wang X, Sun Z, Liu M, Shi H, Wang H, Feng Y, Shao R, Chai R, Li Q, Xing Q, Zhang R, Nogales E, Jin L, He L, Gupta ML Jr, Cowan NJ*, Wang L*. Mutations in TUBB8 and human oocyte meiotic arrest. N Engl J Med. 2016 Jan 21;374(3):223-32.